
Call to action
Global Emergency
- Sepsis: 166M cases and 21M deaths in a single year.
- Superbugs and fungi already kill millions annually.
- AMR could cause 10M deaths per year by 2050.
Economic Shockwave
- AMR adds ≈$66B/year now, rising toward $159B.
- Superbugs may cost the world up to $100T by 2050.
- Every dollar invested can return 28 in benefits.
Americas Under Pressure
- Sepsis drives tens of billions in hospital costs yearly.
- MRSA, ESBL E. coli/Klebsiella, CRE strain ICUs daily.
- Invasive Candida and endemic fungi raise mortality.
Europe’s Resistant Storm
- Europe spends billions managing resistant infections.
- Carbapenem-resistant Klebsiella and MRSA are entrenched.
- Azole-resistant Aspergillus threatens cancer and ICU care.
Africa’s High Toll
- Africa carries the world’s highest AMR death rates.
- ESBL Enterobacterales and MRSA drive severe sepsis.
- Cryptococcus, Candida, Aspergillus hit HIV/TB hardest.
Asia & Middle East Epicenter
- Asia leads global AMR deaths; rates still climbing.
- ESBL/CRE E. coli, Klebsiella, XDR Acinetobacter dominate ICUs.
- C. auris and azole-resistant Aspergillus are spreading.
The Fungal Front
- ≈6.5M invasive fungal infections, 3.8M deaths yearly.
- Candida bloodstream infections can kill most patients.
- Rapid fungal–bacterial diagnostics remain rare at bedside.
Innovation or Regression
- MDR threats are eroding the safety of modern medicine.
- We need faster diagnostics, new drugs, and prevention tech.
- Partner with us to accelerate life-saving innovation now.

Explore the Evidence
- Sepsis global burden (166M cases, 21M deaths)
- Sepsis incidence & mortality (IHME overview)
- Global bacterial AMR burden (1990–2021): [PubMed] | [The Lancet]
- Economic impact of AMR and superbugs: [AMR Solutions] | [IFPMA] | [Harvard Repository]
- Severe fungal disease: incidence, mortality, resistance
- AMR in Africa and Asia (regional context): [Africa] | [Asia]
